Context. The plant Citrus maxima Merr. (Rutaceae), commonly known as shaddock or pomelo is indigenous to tropical parts of Asia. The objective of present study is to evaluate the methanol extract of Citrus maxima leaves for its antitumor activity against Ehrlich's Ascites Carcinoma cell in Swiss albino mice. Experimental design. The antitumor activity of methanol extract of Citrus maxima leaves (MECM) was evaluated against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. 2 × 106 cells were inoculated in different groups of animals. MECM (200 and 400 mg/kg BW i.p.) was administered for nine consecutive days. On day 10th half the animals of different groups were sacrificed for determination of tumor and haematological parameters and the rest half were kept with sufficient food and water ad libitum for determination of increase in life span. Result and Discussions. Oral administration of the extract at the doses of 200 and 400 mg/kg significantly decreased tumor parameters such as tumor volume, viable tumor cell count and increased body weight, hematological parameters and life span in respect of the EAC control mice. Conclusion. Experimental design exhibits significant antitumor activity of the extract (MECM) in a dose dependant manner.
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机译：上下文。植物柑桔。 （芸香科），俗称柚子或柚子，原产于亚洲热带地区。本研究的目的是评估柑桔叶的甲醇提取物对瑞士白化病小鼠中的埃里希氏腹水癌细胞的抗肿瘤活性。实验设计。在瑞士的白化病小鼠中评估了柑桔叶甲醇提取物（MECM）的抗艾氏腹水癌（EAC）细胞系的抗肿瘤活性。在不同的动物组中接种2×106个细胞。连续九天给予MECM（200和400μmg/ kg BW i.p.）。在第10天，处死不同组的动物以测定肿瘤和血液学参数，而其余一半则自由摄取足够的食物和水以测定寿命的延长。结果与讨论。相对于EAC对照小鼠，以200和400μmg/ kg的剂量口服提取物可显着降低肿瘤参数，例如肿瘤体积，可行的肿瘤细胞数量，并增加体重，血液学参数和寿命。结论。实验设计以剂量依赖性方式表现出提取物（MECM）的显着抗肿瘤活性。
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